Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat

Public release date: 17-Sep-2012
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Contact: Professor Les Baillie
baillieL@cf.ac.uk
029-208-75535
Cardiff University

A team of Cardiff University scientists is leading new research to develop a vaccine against anthrax to help counteract the threat of bioterrorism.

Working with scientists from the Republic of Georgia, Turkey and the USA, Professor Les Baillie from Cardiff University's School of Pharmacy and Pharmaceutical Sciences is leading a NATO project to tackle the potential misuse of anthrax.

"Currently the majority of the world's population is susceptible to infection with Bacillus anthracis the bacterium which causes anthrax," according to Professor Baillie, who leads the multi-national research collaboration.

"The US postal attacks in 2001 highlighted the vulnerability of civilian populations and brought home the need to develop effective, rapid, robust medical countermeasures to combat the threat posed by terrorist use of this organism," he added.

It is the growing concern over the threat posed by bioterrorism that has prompted world authorities like NATO through its Science for Peace and Security Programme to support efforts to develop more effective vaccines and medical countermeasures.

Efforts have so far been hampered by the fact that cases of naturally acquired human infection are rare in NATO countries. As a consequence, researchers have been forced to employ animal models to develop new vaccines.

The problem with this approach is the immune responses of animals and humans differ and as a consequence human clinical trials represent an essential element in confirming the efficacy of any new vaccine.

Such trials require access to several thousand volunteers at risk of infection and as such would be almost impossible to perform in Western Europe or the US.

In contrast anthrax represents a significant disease of animals and humans in the Cacuses and Central Asia. For this reason researchers from the UK and US have joined with colleagues from Turkey and the former Soviet republic of Georgia to tackle the problem.

Professor Baillie added: "These unique resources, combined with the expertise of NATO researchers offers us an unparalleled opportunity."

The outputs of this study are expected to underpin the development of future vaccines capable of conferring broad-spectrum, robust protection following minimal dosing.

Such vaccines would impact on two levels, locally they would directly improve the life of workers at risk of contracting anthrax such as farmers, and globally they would contribute to the protection of citizens from the use of anthrax as an agent of bio-terrorism.

An additional benefit of this work will be the establishment of a research centre in Georgia which will support infectious disease research and ultimately improve the lives of all of the people in the region.

###

Notes:

For further information or media interview, please contact:

Professor Les Baillie
Professor of Microbiology
School of Pharmacy and Pharmaceutical Sciences
Cardiff University
Tel: 029 208 75535
Email: baillieL@cf.ac.uk

Chris Jones
Public Relations
Cardiff University
Tel: 029 20 874732
E-mail: jonesc83@cardiff.ac.uk

Cardiff University

Cardiff University is recognised in independent government assessments as one of Britain's leading teaching and research universities and is a member of the Russell Group of the UK's most research intensive universities. Among its academic staff are two Nobel Laureates, including the winner of the 2007 Nobel Prize for Medicine, University President Professor Sir Martin Evans.

Founded by Royal Charter in 1883, today the University combines impressive modern facilities and a dynamic approach to teaching and research. The University's breadth of expertise in research and research-led teaching encompasses: the humanities; the natural, physical, health, life and social sciences; engineering and technology; preparation for a wide range of professions; and a longstanding commitment to lifelong learning. Three major new Research Institutes, offering radical new approaches to neurosciences and mental health, cancer stem cells and sustainable places were announced by the University in 2010.

www.cardiff.ac.uk

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Public release date: 17-Sep-2012
[ | E-mail | Share ]

Contact: Professor Les Baillie
baillieL@cf.ac.uk
029-208-75535
Cardiff University

A team of Cardiff University scientists is leading new research to develop a vaccine against anthrax to help counteract the threat of bioterrorism.

Working with scientists from the Republic of Georgia, Turkey and the USA, Professor Les Baillie from Cardiff University's School of Pharmacy and Pharmaceutical Sciences is leading a NATO project to tackle the potential misuse of anthrax.

"Currently the majority of the world's population is susceptible to infection with Bacillus anthracis the bacterium which causes anthrax," according to Professor Baillie, who leads the multi-national research collaboration.

"The US postal attacks in 2001 highlighted the vulnerability of civilian populations and brought home the need to develop effective, rapid, robust medical countermeasures to combat the threat posed by terrorist use of this organism," he added.

It is the growing concern over the threat posed by bioterrorism that has prompted world authorities like NATO through its Science for Peace and Security Programme to support efforts to develop more effective vaccines and medical countermeasures.

Efforts have so far been hampered by the fact that cases of naturally acquired human infection are rare in NATO countries. As a consequence, researchers have been forced to employ animal models to develop new vaccines.

The problem with this approach is the immune responses of animals and humans differ and as a consequence human clinical trials represent an essential element in confirming the efficacy of any new vaccine.

Such trials require access to several thousand volunteers at risk of infection and as such would be almost impossible to perform in Western Europe or the US.

In contrast anthrax represents a significant disease of animals and humans in the Cacuses and Central Asia. For this reason researchers from the UK and US have joined with colleagues from Turkey and the former Soviet republic of Georgia to tackle the problem.

Professor Baillie added: "These unique resources, combined with the expertise of NATO researchers offers us an unparalleled opportunity."

The outputs of this study are expected to underpin the development of future vaccines capable of conferring broad-spectrum, robust protection following minimal dosing.

Such vaccines would impact on two levels, locally they would directly improve the life of workers at risk of contracting anthrax such as farmers, and globally they would contribute to the protection of citizens from the use of anthrax as an agent of bio-terrorism.

An additional benefit of this work will be the establishment of a research centre in Georgia which will support infectious disease research and ultimately improve the lives of all of the people in the region.

###

Notes:

For further information or media interview, please contact:

Professor Les Baillie
Professor of Microbiology
School of Pharmacy and Pharmaceutical Sciences
Cardiff University
Tel: 029 208 75535
Email: baillieL@cf.ac.uk

Chris Jones
Public Relations
Cardiff University
Tel: 029 20 874732
E-mail: jonesc83@cardiff.ac.uk

Cardiff University

Cardiff University is recognised in independent government assessments as one of Britain's leading teaching and research universities and is a member of the Russell Group of the UK's most research intensive universities. Among its academic staff are two Nobel Laureates, including the winner of the 2007 Nobel Prize for Medicine, University President Professor Sir Martin Evans.

Founded by Royal Charter in 1883, today the University combines impressive modern facilities and a dynamic approach to teaching and research. The University's breadth of expertise in research and research-led teaching encompasses: the humanities; the natural, physical, health, life and social sciences; engineering and technology; preparation for a wide range of professions; and a longstanding commitment to lifelong learning. Three major new Research Institutes, offering radical new approaches to neurosciences and mental health, cancer stem cells and sustainable places were announced by the University in 2010.

www.cardiff.ac.uk

---

[ | E-mail | Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/cu-csb091712.php

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